BioSim Talk #5 開催のご案内

(An IPR seminar series supported by WPI PRIMe and ASPiRE)

日時：2024年9月6日（金）16:00 – 17:30
場所：大阪大学（吹田キャンパス）蛋白質研究所 2階中会議室 + Zoom
（Zoomでの参加をご希望の方は下記までご連絡ください。）
[Meeting ID: 828 3416 4957  /  Passcode: 723870]

[Contact]
Sandhya P. Tiwari
Email: sandhyatiwari[at]protein.osaka-u.ac.jp（[at]は@に置き換えてください。）
Ai Shinobu
Email: shinobu.ai.prime[at]osaka-u.ac.jp（[at]は@に置き換えてください。）

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Integrative Modelling for the Study of Genomic Structure and Function

Speaker: Giovanni Brandani, PhD.
Lecturer, Theoretical Biophysics lab,
Dept. of Biophysics, Graduate Sch. of Science,
Kyoto University

Eukaryotic genomes are tightly packed into the nucleus in the form of chromatin: a complex of DNA and proteins hierarchically organized starting from the basic unit of the nucleosome, up to loops linking together gene promoters to distant enhancers. This 3d organization supports the regulation of genes, but we still lack a clear understanding of this process at the molecular level.

Current computational and in vitro approaches are limited to simple model systems, while the interpretation of in vivo experiments remains a challenge. To move beyond such limitations, I will illustrate a Bayesian integrative approach to create a comprehensive near-atomic-level model of genes based on experimental data.

The model can be a starting point for molecular dynamics simulations exploring the physical principles governing the structure and function of genes, from the organization of chromatin fibers to the communication of enhancers and promoters through transcription factor condensation.